Its typical use is to avoid the "lost update" problem, where a client GETs a resource's state, modifies it, and PUTs it back to the server, when meanwhile a third party has modified the state on the server, leading to a conflict. By requiring requests to be conditional, the server can assure that clients are working with the correct copies.
Responses using this status code SHOULD explain how to resubmit the request successfully. For example:
