diff --git a/platform/firefox/vapi-background.js b/platform/firefox/vapi-background.js
index d960c8f0d..a42174924 100644
--- a/platform/firefox/vapi-background.js
+++ b/platform/firefox/vapi-background.js
@@ -2361,9 +2361,27 @@ vAPI.net.registerListeners = function() {
             null;
     }
 
-    var shouldLoadPopupListenerMessageName = location.host + ':shouldLoadPopup';
-    var shouldLoadPopupListener = function(openerURL, popupTabId) {
-        var uri, openerTabId;
+    var shouldLoadPopupListenerMessageName = location.host + ':shouldLoadPopup',
+        shouldLoadPopupListenerMap = new Map(),
+        shouldLoadPopupListenerMapToD = 0;
+    var shouldLoadPopupListener = function(openerURL, target) {
+        var popupTabId = tabWatcher.tabIdFromTarget(target),
+            popupURL = target.currentURI && target.currentURI.asciiSpec || '',
+            openerTabId,
+            uri;
+        if ( shouldLoadPopupListenerMapToD > Date.now() ) {
+            openerTabId = shouldLoadPopupListenerMap.get(popupURL);
+        }
+
+        // https://github.com/uBlockOrigin/uAssets/issues/255
+        //   Handle chained popups.
+        if ( openerTabId !== undefined ) {
+            shouldLoadPopupListenerMap.set(target.currentURI.asciiSpec, openerTabId);
+            shouldLoadPopupListenerMapToD = Date.now() + 10000;
+            vAPI.tabs.onPopupCreated(popupTabId, openerTabId);
+            return;
+        }
+
         for ( var browser of tabWatcher.browsers() ) {
             uri = browser.currentURI;
 
@@ -2375,15 +2393,16 @@ vAPI.net.registerListeners = function() {
             // believe this may have to do with those very temporary
             // browser objects created when opening a new tab, i.e. related
             // to https://github.com/gorhill/uBlock/issues/212
-            if ( !uri || uri.spec !== openerURL ) {
-                continue;
-            }
+            if ( !uri || uri.spec !== openerURL ) { continue; }
 
             openerTabId = tabWatcher.tabIdFromTarget(browser);
-            if ( openerTabId !== popupTabId ) {
-                vAPI.tabs.onPopupCreated(popupTabId, openerTabId);
-                break;
-            }
+            if ( openerTabId === popupTabId ) { continue; }
+
+            shouldLoadPopupListenerMap = new Map();
+            shouldLoadPopupListenerMapToD = Date.now() + 10000;
+            shouldLoadPopupListenerMap.set(popupURL, openerTabId);
+            vAPI.tabs.onPopupCreated(popupTabId, openerTabId);
+            break;
         }
     };
     var shouldLoadPopupListenerAsync = function(e) {
@@ -2391,10 +2410,7 @@ vAPI.net.registerListeners = function() {
             return;
         }
         // We are handling a synchronous message: do not block.
-        vAPI.setTimeout(
-            shouldLoadPopupListener.bind(null, e.data, tabWatcher.tabIdFromTarget(e.target)),
-            1
-        );
+        vAPI.setTimeout(shouldLoadPopupListener.bind(null, e.data, e.target), 1);
     };
 
     vAPI.messaging.globalMessageManager.addMessageListener(
diff --git a/src/js/tab.js b/src/js/tab.js
index ffad7a4df..af8c68a63 100644
--- a/src/js/tab.js
+++ b/src/js/tab.js
@@ -568,22 +568,25 @@ vAPI.tabs.onPopupUpdated = (function() {
         //   URL.
         // https://github.com/gorhill/uBlock/issues/1735
         //   Do not bail out on `data:` URI, they are commonly used for popups.
+        // https://github.com/uBlockOrigin/uAssets/issues/255
+        //   Do not bail out on `about:blank`: an `about:blank` popup can be
+        //   opened, with the sole purpose to serve as an intermediary in
+        //   a sequence of chained popups.
         if (
             context.requestHostname === '' &&
-            targetURL.startsWith('data:') === false
+            targetURL.startsWith('data:') === false &&
+            targetURL !== 'about:blank'
         ) {
             return '';
         }
 
         // Dynamic filtering makes sense only when we have a valid hostname.
         if ( openerHostname !== '' ) {
-            // Check user switch first
-            if (
-                typeof clickedURL === 'string' &&
-                areDifferentURLs(targetURL, clickedURL) &&
-                µb.hnSwitches.evaluateZ('no-popups', openerHostname)
-            ) {
-                return 'ub:no-popups: ' + µb.hnSwitches.z + ' true';
+            // Check per-site switch first
+            if ( µb.hnSwitches.evaluateZ('no-popups', openerHostname) ) {
+                if ( typeof clickedURL !== 'string' || areDifferentURLs(targetURL, clickedURL) ) {
+                    return 'ub:no-popups: ' + µb.hnSwitches.z + ' true';
+                }
             }
 
             // https://github.com/gorhill/uBlock/issues/581