diff --git a/Utilities/Config.cpp b/Utilities/Config.cpp
index def495da74..962a36385b 100644
--- a/Utilities/Config.cpp
+++ b/Utilities/Config.cpp
@@ -17,8 +17,8 @@ namespace cfg
 		}
 	}
 
-	_base::_base(type _type, node* owner, const std::string& name)
-		: m_type(_type)
+	_base::_base(type _type, node* owner, const std::string& name, bool dynamic)
+		: m_type(_type), m_dynamic(dynamic)
 	{
 		for (const auto& pair : owner->m_nodes)
 		{
@@ -31,7 +31,7 @@ namespace cfg
 		owner->m_nodes.emplace_back(name, this);
 	}
 
-	bool _base::from_string(const std::string&)
+	bool _base::from_string(const std::string&, bool)
 	{
 		fmt::throw_exception("from_string() purecall" HERE);
 	}
@@ -46,7 +46,7 @@ namespace cfg
 
 	// Incrementally load config entries from YAML::Node.
 	// The config value is preserved if the corresponding YAML node doesn't exist.
-	static void decode(const YAML::Node& data, class _base& rhs);
+	static void decode(const YAML::Node& data, class _base& rhs, bool dynamic = false);
 }
 
 std::vector<std::string> cfg::make_int_range(s64 min, s64 max)
@@ -212,8 +212,13 @@ void cfg::encode(YAML::Emitter& out, const cfg::_base& rhs)
 	}
 }
 
-void cfg::decode(const YAML::Node& data, cfg::_base& rhs)
+void cfg::decode(const YAML::Node& data, cfg::_base& rhs, bool dynamic)
 {
+	if (dynamic && !rhs.get_is_dynamic())
+	{
+		return;
+	}
+
 	switch (rhs.get_type())
 	{
 	case type::node:
@@ -232,7 +237,7 @@ void cfg::decode(const YAML::Node& data, cfg::_base& rhs)
 			{
 				if (_pair.first == pair.first.Scalar())
 				{
-					decode(pair.second, *_pair.second);
+					decode(pair.second, *_pair.second, dynamic);
 				}
 			}
 		}
@@ -295,9 +300,9 @@ std::string cfg::node::to_string() const
 	return {out.c_str(), out.size()};
 }
 
-bool cfg::node::from_string(const std::string& value) try
+bool cfg::node::from_string(const std::string& value, bool dynamic) try
 {
-	cfg::decode(YAML::Load(value), *this);
+	cfg::decode(YAML::Load(value), *this, dynamic);
 	return true;
 }
 catch (const std::exception& e)
diff --git a/Utilities/Config.h b/Utilities/Config.h
index e05e692db5..2a5686a64b 100644
--- a/Utilities/Config.h
+++ b/Utilities/Config.h
@@ -42,11 +42,13 @@ namespace cfg
 		const type m_type;
 
 	protected:
+		bool m_dynamic = true;
+
 		// Ownerless entry constructor
 		_base(type _type);
 
 		// Owned entry constructor
-		_base(type _type, class node* owner, const std::string& name);
+		_base(type _type, class node* owner, const std::string& name, bool dynamic = true);
 
 	public:
 		_base(const _base&) = delete;
@@ -56,6 +58,9 @@ namespace cfg
 		// Get type
 		type get_type() const { return m_type; }
 
+		// Get dynamic property for reloading configs during games
+		bool get_is_dynamic() const { return m_dynamic; };
+
 		// Reset defaults
 		virtual void from_default() = 0;
 
@@ -66,7 +71,7 @@ namespace cfg
 		}
 
 		// Try to convert from string (optional)
-		virtual bool from_string(const std::string&);
+		virtual bool from_string(const std::string&, bool /*dynamic*/ = false);
 
 		// Get string list (optional)
 		virtual std::vector<std::string> to_list() const
@@ -93,8 +98,8 @@ namespace cfg
 		}
 
 		// Registered node constructor
-		node(node* owner, const std::string& name)
-			: _base(type::node, owner, name)
+		node(node* owner, const std::string& name, bool dynamic = true)
+			: _base(type::node, owner, name, dynamic)
 		{
 		}
 
@@ -108,7 +113,7 @@ namespace cfg
 		std::string to_string() const override;
 
 		// Deserialize node
-		bool from_string(const std::string& value) override;
+		bool from_string(const std::string& value, bool dynamic = false) override;
 
 		// Set default values
 		void from_default() override;
@@ -121,8 +126,8 @@ namespace cfg
 	public:
 		bool def;
 
-		_bool(node* owner, const std::string& name, bool def = false)
-			: _base(type::_bool, owner, name)
+		_bool(node* owner, const std::string& name, bool def = false, bool dynamic = false)
+			: _base(type::_bool, owner, name, dynamic)
 			, m_value(def)
 			, def(def)
 		{
@@ -145,7 +150,7 @@ namespace cfg
 			return m_value ? "true" : "false";
 		}
 
-		bool from_string(const std::string& value) override
+		bool from_string(const std::string& value, bool /*dynamic*/ = false) override
 		{
 			if (value == "false")
 				m_value = false;
@@ -172,8 +177,8 @@ namespace cfg
 	public:
 		const T def;
 
-		_enum(node* owner, const std::string& name, T value = {})
-			: _base(type::_enum, owner, name)
+		_enum(node* owner, const std::string& name, T value = {}, bool dynamic = false)
+			: _base(type::_enum, owner, name, dynamic)
 			, m_value(value)
 			, def(value)
 		{
@@ -201,7 +206,7 @@ namespace cfg
 			return result; // TODO: ???
 		}
 
-		bool from_string(const std::string& value) override
+		bool from_string(const std::string& value, bool /*dynamic*/ = false) override
 		{
 			u64 result;
 
@@ -239,8 +244,8 @@ namespace cfg
 		static const s64 max = Max;
 		static const s64 min = Min;
 
-		_int(node* owner, const std::string& name, int_type def = std::min<int_type>(Max, std::max<int_type>(Min, 0)))
-			: _base(type::_int, owner, name)
+		_int(node* owner, const std::string& name, int_type def = std::min<int_type>(Max, std::max<int_type>(Min, 0)), bool dynamic = false)
+			: _base(type::_int, owner, name, dynamic)
 			, m_value(def)
 			, def(def)
 		{
@@ -266,7 +271,7 @@ namespace cfg
 			return std::to_string(m_value);
 		}
 
-		bool from_string(const std::string& value) override
+		bool from_string(const std::string& value, bool /*dynamic*/ = false) override
 		{
 			s64 result;
 			if (try_to_int64(&result, value, Min, Max))
@@ -304,8 +309,8 @@ namespace cfg
 	public:
 		std::string def;
 
-		string(node* owner, const std::string& name, const std::string& def = {})
-			: _base(type::string, owner, name)
+		string(node* owner, const std::string& name, const std::string& def = {}, bool dynamic = false)
+			: _base(type::string, owner, name, dynamic)
 			, m_name(name)
 			, m_value(def)
 			, def(def)
@@ -339,7 +344,7 @@ namespace cfg
 			return m_value;
 		}
 
-		bool from_string(const std::string& value) override
+		bool from_string(const std::string& value, bool /*dynamic*/ = false) override
 		{
 			m_value = value;
 			return true;
@@ -353,8 +358,8 @@ namespace cfg
 
 	public:
 		// Default value is empty list in current implementation
-		set_entry(node* owner, const std::string& name)
-			: _base(type::set, owner, name)
+		set_entry(node* owner, const std::string& name, bool dynamic = false)
+			: _base(type::set, owner, name, dynamic)
 		{
 		}
 
diff --git a/rpcs3/Crypto/unself.cpp b/rpcs3/Crypto/unself.cpp
index 0b0f6f23b4..961e30591f 100644
--- a/rpcs3/Crypto/unself.cpp
+++ b/rpcs3/Crypto/unself.cpp
@@ -1081,7 +1081,7 @@ bool SELFDecrypter::DecryptNPDRM(u8 *metadata, u32 metadata_size)
 	// If not, the data has no NPDRM layer.
 	if (!ctrl)
 	{
-		LOG_NOTICE(LOADER, "SELF: No NPDRM control info found!");
+		LOG_TRACE(LOADER, "SELF: No NPDRM control info found!");
 		return true;
 	}
 
diff --git a/rpcs3/Emu/System.cpp b/rpcs3/Emu/System.cpp
index 72d7f5370d..60bb91feb9 100644
--- a/rpcs3/Emu/System.cpp
+++ b/rpcs3/Emu/System.cpp
@@ -331,6 +331,7 @@ void Emulator::Init()
 	if (const fs::file cfg_file{cfg_path, fs::read + fs::create})
 	{
 		g_cfg.from_string(cfg_file.to_string());
+		g_cfg.name = cfg_path;
 	}
 	else
 	{
@@ -1021,6 +1022,7 @@ void Emulator::Load(const std::string& title_id, bool add_only, bool force_globa
 			{
 				LOG_NOTICE(LOADER, "Applying custom config: %s", config_path_new);
 				g_cfg.from_string(cfg_file.to_string());
+				g_cfg.name = config_path_new;
 			}
 
 			// Load custom config-3
diff --git a/rpcs3/Emu/System.h b/rpcs3/Emu/System.h
index 42b7bebbcb..bc9e2dad4c 100644
--- a/rpcs3/Emu/System.h
+++ b/rpcs3/Emu/System.h
@@ -514,23 +514,23 @@ struct cfg_root : cfg::node
 		{
 			node_perf_overlay(cfg::node* _this) : cfg::node(_this, "Performance Overlay") {}
 
-			cfg::_bool perf_overlay_enabled{this, "Enabled", false};
-			cfg::_bool framerate_graph_enabled{ this, "Enable Framerate Graph", false };
-			cfg::_bool frametime_graph_enabled{ this, "Enable Frametime Graph", false };
-			cfg::_enum<detail_level> level{this, "Detail level", detail_level::medium};
-			cfg::_int<30, 5000> update_interval{ this, "Metrics update interval (ms)", 350 };
-			cfg::_int<4, 36> font_size{ this, "Font size (px)", 10 };
-			cfg::_enum<screen_quadrant> position{this, "Position", screen_quadrant::top_left};
-			cfg::string font{this, "Font", "n023055ms.ttf"};
-			cfg::_int<0, 1280> margin_x{this, "Horizontal Margin (px)", 50}; // horizontal distance to the screen border relative to the screen_quadrant in px
-			cfg::_int<0, 720> margin_y{this, "Vertical Margin (px)", 50}; // vertical distance to the screen border relative to the screen_quadrant in px
-			cfg::_bool center_x{ this, "Center Horizontally", false };
-			cfg::_bool center_y{ this, "Center Vertically", false };
-			cfg::_int<0, 100> opacity{this, "Opacity (%)", 70};
-			cfg::string color_body{ this, "Body Color (hex)", "#FFE138FF" };
-			cfg::string background_body{ this, "Body Background (hex)", "#002339FF" };
-			cfg::string color_title{ this, "Title Color (hex)", "#F26C24FF" };
-			cfg::string background_title{ this, "Title Background (hex)", "#00000000" };
+			cfg::_bool perf_overlay_enabled{ this, "Enabled", false, true };
+			cfg::_bool framerate_graph_enabled{ this, "Enable Framerate Graph", false, true };
+			cfg::_bool frametime_graph_enabled{ this, "Enable Frametime Graph", false, true };
+			cfg::_enum<detail_level> level{ this, "Detail level", detail_level::medium, true };
+			cfg::_int<30, 5000> update_interval{ this, "Metrics update interval (ms)", 350, true };
+			cfg::_int<4, 36> font_size{ this, "Font size (px)", 10, true };
+			cfg::_enum<screen_quadrant> position{ this, "Position", screen_quadrant::top_left, true };
+			cfg::string font{ this, "Font", "n023055ms.ttf", true };
+			cfg::_int<0, 1280> margin_x{ this, "Horizontal Margin (px)", 50, true }; // horizontal distance to the screen border relative to the screen_quadrant in px
+			cfg::_int<0, 720> margin_y{ this, "Vertical Margin (px)", 50, true }; // vertical distance to the screen border relative to the screen_quadrant in px
+			cfg::_bool center_x{ this, "Center Horizontally", false, true };
+			cfg::_bool center_y{ this, "Center Vertically", false, true };
+			cfg::_int<0, 100> opacity{ this, "Opacity (%)", 70, true };
+			cfg::string color_body{ this, "Body Color (hex)", "#FFE138FF", true };
+			cfg::string background_body{ this, "Body Background (hex)", "#002339FF", true };
+			cfg::string color_title{ this, "Title Color (hex)", "#F26C24FF", true };
+			cfg::string background_title{ this, "Title Background (hex)", "#00000000", true };
 
 		} perf_overlay{this};
 
@@ -538,8 +538,8 @@ struct cfg_root : cfg::node
 		{
 			node_shader_compilation_hint(cfg::node* _this) : cfg::node(_this, "Shader Compilation Hint") {}
 
-			cfg::_int<0, 1280> pos_x{this, "Position X (px)", 20}; // horizontal position starting from the upper border in px
-			cfg::_int<0, 720> pos_y{this, "Position Y (px)", 690}; // vertical position starting from the left border in px
+			cfg::_int<0, 1280> pos_x{ this, "Position X (px)", 20, true }; // horizontal position starting from the upper border in px
+			cfg::_int<0, 720> pos_y{ this, "Position Y (px)", 690, true }; // vertical position starting from the left border in px
 
 		} shader_compilation_hint{this};
 
@@ -547,9 +547,9 @@ struct cfg_root : cfg::node
 		{
 			node_shader_preloading_dialog(cfg::node* _this) : cfg::node(_this, "Shader Loading Dialog"){}
 
-			cfg::_bool use_custom_background{this, "Allow custom background", true};
-			cfg::_int<0, 100> darkening_strength{this, "Darkening effect strength", 30};
-			cfg::_int<0, 100> blur_strength{this, "Blur effect strength", 0};
+			cfg::_bool use_custom_background{ this, "Allow custom background", true, true };
+			cfg::_int<0, 100> darkening_strength{ this, "Darkening effect strength", 30, true };
+			cfg::_int<0, 100> blur_strength{ this, "Blur effect strength", 0, true };
 
 		} shader_preloading_dialog{this};
 
@@ -581,7 +581,6 @@ struct cfg_root : cfg::node
 
 		cfg::_enum<keyboard_handler> keyboard{this, "Keyboard", keyboard_handler::null};
 		cfg::_enum<mouse_handler> mouse{this, "Mouse", mouse_handler::basic};
-		cfg::_enum<pad_handler> pad{this, "Pad", pad_handler::keyboard};
 		cfg::_enum<camera_handler> camera{this, "Camera", camera_handler::null};
 		cfg::_enum<fake_camera_type> camera_type{this, "Camera type", fake_camera_type::unknown};
 		cfg::_enum<move_handler> move{this, "Move", move_handler::null};
@@ -610,19 +609,21 @@ struct cfg_root : cfg::node
 	{
 		node_misc(cfg::node* _this) : cfg::node(_this, "Miscellaneous") {}
 
-		cfg::_bool autostart{this, "Automatically start games after boot", true};
-		cfg::_bool autoexit{this, "Exit RPCS3 when process finishes"};
-		cfg::_bool start_fullscreen{ this, "Start games in fullscreen mode" };
+		cfg::_bool autostart{ this, "Automatically start games after boot", true, true };
+		cfg::_bool autoexit{ this, "Exit RPCS3 when process finishes", false, true };
+		cfg::_bool start_fullscreen{ this, "Start games in fullscreen mode", false, true };
 		cfg::_bool prevent_display_sleep{ this, "Prevent display sleep while running games", true};
-		cfg::_bool show_fps_in_title{ this, "Show FPS counter in window title", true};
-		cfg::_bool show_trophy_popups{ this, "Show trophy popups", true};
-		cfg::_bool show_shader_compilation_hint{ this, "Show shader compilation hint", true };
+		cfg::_bool show_fps_in_title{ this, "Show FPS counter in window title", true, true };
+		cfg::_bool show_trophy_popups{ this, "Show trophy popups", true, true };
+		cfg::_bool show_shader_compilation_hint{ this, "Show shader compilation hint", true, true };
 		cfg::_bool use_native_interface{ this, "Use native user interface", true };
 		cfg::string gdb_server{this, "GDB Server", "127.0.0.1:2345"};
 
 	} misc{this};
 
 	cfg::log_entry log{this, "Log"};
+
+	std::string name;
 };
 
 extern cfg_root g_cfg;
diff --git a/rpcs3/rpcs3qt/emu_settings.cpp b/rpcs3/rpcs3qt/emu_settings.cpp
index 864b4e6bf2..28dde5dfa9 100644
--- a/rpcs3/rpcs3qt/emu_settings.cpp
+++ b/rpcs3/rpcs3qt/emu_settings.cpp
@@ -296,19 +296,36 @@ void emu_settings::SaveSettings()
 	YAML::Emitter out;
 	emitData(out, m_currentSettings);
 
-	if (!m_title_id.empty())
+	std::string config_name;
+
+	if (m_title_id.empty())
 	{
-		config = fs::file(Emulator::GetCustomConfigPath(m_title_id), fs::read + fs::write + fs::create);
+		config_name = fs::get_config_dir() + "/config.yml";
 	}
 	else
 	{
-		config = fs::file(fs::get_config_dir() + "/config.yml", fs::read + fs::write + fs::create);
+		config_name = Emulator::GetCustomConfigPath(m_title_id);
 	}
 
+	config = fs::file(config_name, fs::read + fs::write + fs::create);
+
 	// Save config
 	config.seek(0);
 	config.trunc(0);
 	config.write(out.c_str(), out.size());
+
+	// Check if the running config/title is the same as the edited config/title.
+	if (config_name == g_cfg.name || m_title_id == Emu.GetTitleID())
+	{
+		// Update current config
+		g_cfg.from_string(config.to_string(), true);
+
+		if (!Emu.IsStopped()) // Don't spam the log while emulation is stopped. The config will be logged on boot anyway.
+		{
+			LOG_NOTICE(LOADER, "Updated configuration:\n%s\n", g_cfg.to_string());
+		}
+	}
+
 	config.close();
 }
 
diff --git a/rpcs3/rpcs3qt/game_list_frame.cpp b/rpcs3/rpcs3qt/game_list_frame.cpp
index 156a3fc374..dc7517e705 100644
--- a/rpcs3/rpcs3qt/game_list_frame.cpp
+++ b/rpcs3/rpcs3qt/game_list_frame.cpp
@@ -967,10 +967,14 @@ void game_list_frame::ShowContextMenu(const QPoint &pos)
 	connect(configure, &QAction::triggered, [=]
 	{
 		settings_dialog dlg(m_gui_settings, m_emu_settings, 0, this, &currGame);
-		if (dlg.exec() == QDialog::Accepted && !gameinfo->hasCustomConfig)
+		if (dlg.exec() == QDialog::Accepted)
 		{
-			gameinfo->hasCustomConfig = true;
-			ShowCustomConfigIcon(item);
+			if (!gameinfo->hasCustomConfig)
+			{
+				gameinfo->hasCustomConfig = true;
+				ShowCustomConfigIcon(item);
+			}
+			Q_EMIT NotifyEmuSettingsChange();
 		}
 	});
 	connect(pad_configure, &QAction::triggered, [=]
diff --git a/rpcs3/rpcs3qt/game_list_frame.h b/rpcs3/rpcs3qt/game_list_frame.h
index 31e82346a8..7d9696e6dd 100644
--- a/rpcs3/rpcs3qt/game_list_frame.h
+++ b/rpcs3/rpcs3qt/game_list_frame.h
@@ -230,6 +230,7 @@ Q_SIGNALS:
 	void GameListFrameClosed();
 	void RequestBoot(const game_info& game, bool force_global_config = false);
 	void RequestIconSizeChange(const int& val);
+	void NotifyEmuSettingsChange();
 protected:
 	/** Override inherited method from Qt to allow signalling when close happened.*/
 	void closeEvent(QCloseEvent* event) override;
diff --git a/rpcs3/rpcs3qt/main_window.cpp b/rpcs3/rpcs3qt/main_window.cpp
index 67f567b246..f941a7a2a5 100644
--- a/rpcs3/rpcs3qt/main_window.cpp
+++ b/rpcs3/rpcs3qt/main_window.cpp
@@ -1593,6 +1593,8 @@ void main_window::CreateDockWindows()
 	{
 		Boot(game->info.path, game->info.serial, false, false, force_global_config);
 	});
+
+	connect(m_gameListFrame, &game_list_frame::NotifyEmuSettingsChange, this, &main_window::NotifyEmuSettingsChange);
 }
 
 void main_window::ConfigureGuiFromSettings(bool configure_all)